ABSTRACT
Los pacientes pediátricos oncológicos con frecuencia presentan lesiones orales debido a su neoplasia o como efecto colateral del tratamiento. El objetivo de este estudio fue comparar la prevalencia de patologías de la mucosa oral en niños con cáncer que fueron hospitalizados y tratados con quimioterapia en el Hospital Regional de Concepción, en los años 1997 y 2007. Se realizó un estudio descriptivo retrospectivo longitudinal en datas de 148 pacientes (74 cada año) con patologías neoplásicas en tratamiento con quimioterapia (Leucemias, linfomas, tumores del Sistema Nervioso Central y otros), registrando sus datos generales y la patología bucal (mucositis (M), candidiasis (C), lesiones por Virus Herpes tipo 1 (VHS) y síndromes hemorragíparos (H) . Los datos se resumieron en tablas anuales y fueron sometidos a análisis estadísticos. Se encontró una disminución significativa del número de pacientes con patologías bucales en el año 2007 en relación al año 1997 (P<0.05, Tet de Fisher). Además se encontró una tendencia a la baja en los pacientes con candidiasis y con mucositis en el año 2007 en comparación con 1997. Es necesario seguir estudiando medidas para prevenir, diagnosticar y/o tratar tempranamente las patologías orales de los pacientes en tratamiento antineoplásico.
Pediatric oncology patients frequently have oral lesions due to malignancy or as a side effect of treatment. The aim of this study was to compare the prevalence of oral pathologies in oncology patients hospitalized and treated at the Regional Hospital of Concepción, Chile, in the years 1997 and 2007. A retrospective study was carried out in 74 patients each year. Patients suffered from acute lymphoblastic leukemia, acute myeloblastic leukemia, central nervous system tumors, lymphomas and other neoplasms. General data (age, gender, oncologic disease) and presence of oral pathologies (candidiasis, mucositis post-chemotherapy, herpetic lesions and hemorrhage) were obtained from their clinical records. Data was analyzed for statistical differences. A significant reduction in the number of patients with oral pathologies was found in 2007 in comparison to 1997 (P<0.05, Fisher´s test). In addition, candidiasis and oral mucositis showed less prevalence in 2007 as compared to 1997, although no significant differences were found. For the relevance of oral pathologies in the chemotherapy it´s important to continue studies about prevention, early detection and treatment of oral pathologies.
Subject(s)
Humans , Male , Female , Child , Antineoplastic Agents/adverse effects , Mouth Diseases/epidemiology , Mouth Diseases/chemically induced , Child, Hospitalized , Candidiasis, Oral/epidemiology , Candidiasis, Oral/chemically induced , Chile/epidemiology , Herpes Simplex/epidemiology , Herpes Simplex/chemically induced , Longitudinal Studies , Leukemia/drug therapy , Lymphoma/drug therapy , Mucositis/epidemiology , Mucositis/chemically induced , Nervous System Neoplasms/drug therapy , Prevalence , Retrospective StudiesABSTRACT
The purpose of this study was to evaluate the influence the use of homogenization of different proportions of milk--which allow to increase the yield in the process and probably to improve sensorial characteristics of the cheese--has on the ripening of low fat Chanco cheese. Five treatments (three replicates each) were studied, two corresponded to control (normal fat and low fat) and the other three treatments were low fat using partially homogenized milk in the following percentages of the total volume of milk; 12.5, 25 and 50 per cent. Standard methodology was used to monitor the evolution of ripening in terms of moisture, fat and total protein content, ripening index (NS/NT per cent), lipolysis (ADV), pH, sensorial quality and micro structure of the product. The low fat treatments with homogenized milk showed less fat losses in the whey and consequently increased yields. This study allowed us to know the low fat Chanco cheese maturation profile, low fat treatments with homogenisation showed a higher degree of lipolysis than the non--homogenized low-fat control although it was lower than normal fat control. No differences in terms of the development of proteolysis were observed. The low--fat homogenized treatments did not show improvement in the flavor neither in the cheese firmness probably due to the short ripening period (21 days) of this cheese variety, nevertheless T3 presented some advantages which could be improved applying simultaneously another technological helps.